Metformin as first-line treatment for type 2 diabetes

Metformin for prevention of type 2 diabetes.

OBJECTIVE To evaluate evidence from the medical literature that metformin is effective in preventing type 2 diabetes. DATA SOURCES Primary literature was accessed via a MEDLINE search (1966-December 2003) using the terms metformin, type 2 diabetes, and prevention. DATA SYNTHESIS Two studies evaluated metformin's potential to prevent type 2 diabetes, finding that metformin maintained or redu...

Pharmacogenomic approach in type 2 diabetes treatment

Introduction: Type 2 diabetes (T2D) is chronic health caused by the interaction between genetic and environmental factors that results in high blood glucose. The evidence-based guidelines for diabetes management are mainly based on lifestyle changes, control of risk factors, and the management of blood glucose levels. Although numerous antidiabetic agents have been developed over time, T2D trea...

Lifestyle Modification Is the First Line Treatment for Type 2 Diabetes

Metformin and Exercise in Type 2 Diabetes

OBJECTIVE To determine the effect of metformin on the acute metabolic response to submaximal exercise, the effect of exercise on plasma metformin concentrations, and the interaction between metformin and exercise on the subsequent response to a standardized meal. RESEARCH DESIGN AND METHODS Ten participants with type 2 diabetes were recruited for this randomized crossover study. Metformin or ...

Metformin and Cancer in Type 2 Diabetes

Corresponding author: Hyeong Kyu Park Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul 140-743, Korea E-mail: [email protected] Many epidemiologic studies have demonstrated a link between type 2 diabetes and an increased risk of certain cancers, and cancer-related mortality [1,2]. A number of me...